![]() ![]() SAMHD1, a global restriction factor, and FEZ1, a brain-specific factor, have been shown to restrict viral replication by endonuclease/ATPase activity, and inhibiting nuclear import, respectively. Astrocytes lack entry receptors for HIV, yet upon entry, the virus is unable to induce a productive infection, which suggests presence of intracellular factors that play a role in this restriction. In the CNS, microglial cells support productive HIV replication while astrocytes restrict it. In the bloodstream, resting CD4+ T-cells are widely studied as an HIV reservoir, supporting low-levels of viral replication. The viremia of individuals on cART is decreased to undetectable levels, although the virus is not completely eliminated, suggesting the presence of viral reservoirs responsible for long-term effects of infection. One such effect, HIV-associated neurocognitive disorder (HAND), is a set of cognitive and motor defects developed from early infection of the CNS. With more people living with HIV, long-term effects of the infection are becoming increasingly important to study. Title: Interplay of Cellular Restriction Factors and Methamphetamine in HIV-Infected Astrocytes – by Alaa Abdelmageed Ahmed.Ībstract: Since its introduction in 1996, cART has been most effective in reducing AIDS-related mmortality. Since joining the laboratory of Stephen Dewhurst, Ph.D last year, Alaa has focused her research towards improving LAIV Efficacy and understanding methods underlying HIV silencing in astrocytes.Īlaa’s thesis proposal is can be reviewed below. BGG graduate student Alaa Ahemd passed her qualifying exam on Thursday, October 13th. ![]()
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